| Rank | City | 2007 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 123,511 | 0.6% |
| 2 | Charleston | 111,055 | 1.9% |
| 3 | North Charleston | 89,907 | 1.6% |
| 4 | Mount Pleasant | 62,251 | 4.1% |
| 5 | Rock Hill | 61,830 | 3.3% |
| 6 | Greenville | 57,912 | 0.3% |
| 7 | Summerville | 41,325 | 6.5% |
| 8 | Sumter | 38,882 | -0.7% |
| 9 | Spartanburg | 38,821 | -0.6% |
| 10 | Goose Creek | 35,006 | 1.7% |
| 11 | Hilton Head Island | 34,368 | 0.2% |
| 12 | Florence | 31,930 | 0.2% |
| 13 | Myrtle Beach | 29,107 | 3.1% |
| 14 | Aiken | 28,657 | 1.5% |
| 15 | Anderson | 26,381 | 0.2% |
| 16 | Greer | 22,567 | 4.0% |
| 17 | Greenwood | 22,404 | 0.0% |
| 18 | Mauldin | 19,875 | 4.1% |
| 19 | North Augusta | 19,753 | 1.8% |
| 20 | Easley | 19,331 | 1.1% |
| 21 | Simpsonville | 16,151 | 1.4% |
| 22 | North Myrtle Beach | 15,033 | 4.8% |
| 23 | Hanahan | 14,728 | 2.1% |
| 24 | Conway | 14,310 | 1.9% |
| 25 | Lexington | 14,101 | 4.8% |
| 26 | West Columbia | 13,644 | 0.3% |
| 27 | Gaffney | 12,852 | -0.1% |
| 28 | Orangeburg | 12,649 | -0.3% |
| 29 | Cayce | 12,534 | 0.4% |
| 30 | Clemson | 12,453 | 0.8% |
| 31 | Beaufort | 11,994 | -1.0% |
| 32 | Irmo | 11,469 | 0.3% |
| 33 | Newberry | 10,577 | 0.4% |
| 34 | Port Royal | 10,278 | 1.5% |
| 35 | Forest Acres | 9,919 | -0.8% |
| 36 | Lancaster | 9,482 | 2.2% |
| 37 | Laurens | 9,479 | -0.4% |
| 38 | Fort Mill | 8,966 | 1.8% |
| 39 | Bennettsville | 8,952 | -1.0% |
| 40 | Clinton | 8,926 | -0.4% |
| 41 | Georgetown | 8,585 | -0.8% |
| 42 | Union | 8,146 | -1.3% |
| 43 | Seneca | 7,906 | 0.4% |
| 44 | Bluffton | 7,762 | 22.5% |
| 45 | York | 7,487 | 1.1% |
| 46 | Hartsville | 7,380 | -0.4% |
| 47 | Fountain Inn | 7,249 | 2.5% |
| 48 | Camden | 6,964 | 0.7% |
| 49 | Marion | 6,812 | -0.6% |
| 50 | Moncks Corner | 6,751 | 1.4% |
| 51 | Lake City | 6,636 | 0.4% |
| 52 | Darlington | 6,558 | -0.6% |
| 53 | Dillon | 6,415 | -0.2% |
| 54 | Chester | 6,046 | -1.1% |
| 55 | Walterboro | 5,614 | 0.8% |
| 56 | Abbeville | 5,576 | -0.9% |
| 57 | Batesburg-Leesville | 5,559 | 0.1% |
| 58 | Cheraw | 5,381 | -0.6% |
| 59 | Surfside Beach | 4,820 | 1.4% |
| 60 | Barnwell | 4,798 | -0.6% |
| 61 | Mullins | 4,742 | -0.9% |
| 62 | Isle of Palms | 4,736 | 0.6% |
| 63 | Tega Cay | 4,675 | 1.6% |
| 64 | Hollywood | 4,581 | 1.6% |
| 65 | Belton | 4,551 | 0.3% |
| 66 | Clover | 4,469 | 1.7% |
| 67 | Edgefield | 4,393 | -0.2% |
| 68 | Travelers Rest | 4,352 | 1.1% |
| 69 | Woodruff | 4,107 | -0.6% |
| 70 | Central | 4,072 | 1.7% |
| 71 | Manning | 3,905 | -0.5% |
| 72 | Williamston | 3,879 | 0.3% |
| 73 | Bishopville | 3,810 | 0.6% |
| 74 | Allendale | 3,729 | -1.4% |
| 75 | Winnsboro | 3,698 | -0.5% |
| 76 | Walhalla | 3,666 | -0.6% |
| 77 | Honea Path | 3,613 | 0.3% |
| 78 | Bamberg | 3,467 | -1.2% |
| 79 | Kingstree | 3,218 | -1.9% |
| 80 | Williston | 3,181 | -0.5% |
| 81 | Fairfax | 3,118 | -0.4% |
| 82 | Duncan | 3,075 | 0.6% |
| 83 | Denmark | 3,064 | -1.3% |
| 84 | Pendleton | 3,061 | 0.4% |
| 85 | Liberty | 3,042 | 0.2% |
| 86 | Pickens | 2,983 | -0.3% |
| 87 | Andrews | 2,980 | -0.5% |
| 88 | Saluda | 2,974 | -0.6% |
| 89 | Lyman | 2,896 | 0.5% |
| 90 | Blackville | 2,861 | -0.6% |
| 91 | Hampton | 2,750 | -0.5% |
| 92 | Pacolet | 2,743 | 0.0% |
| 93 | Springdale | 2,697 | 0.3% |
| 94 | McCormick | 2,674 | 0.1% |
| 95 | Westminster | 2,663 | -0.5% |
| 96 | Burnettown | 2,647 | 0.1% |
| 97 | Ridgeland | 2,627 | 0.1% |
| 98 | Landrum | 2,553 | 0.4% |
| 99 | Pageland | 2,492 | -0.2% |
| 100 | Wellford | 2,481 | 0.4% |
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