| Rank | City | 1880 Population | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Philadelphia | 847,170 | 2.3% |
| 2 | Pittsburgh | 156,389 | 6.2% |
| 3 | Allegheny | 78,682 | 4.0% |
| 4 | Scranton | 45,850 | 2.7% |
| 5 | Reading | 43,278 | 2.5% |
| 6 | Erie | 27,737 | 3.5% |
| 7 | Lancaster | 25,769 | 2.4% |
| 8 | Wilkes-Barre | 23,339 | – |
In 1880, the largest city in Pennsylvania was Philadelphia, with a population of 847,170. The second largest city is Pittsburgh, with a population of 156,389.
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