Rank	City	2022 Population (Est.)	Growth Rate (Annual)
1	Portland	68,313	-0.2%
2	Lewiston	36,617	-0.4%
3	Bangor	31,921	0.5%
4	South Portland	26,993	1.7%
5	Auburn	24,033	0.4%
6	Biddeford	22,569	0.3%
7	Sanford	22,135	0.8%
8	Saco	20,669	1.3%
9	Westbrook	20,572	0.8%
10	Augusta	18,968	0.2%
11	Waterville	15,959	0.1%
12	Brewer	9,636	-0.0%
13	Bath	8,788	0.5%
14	Presque Isle	8,777	-0.4%
15	Ellsworth	8,531	1.7%
16	Old Town	7,372	–
17	Caribou	7,367	-0.2%
18	Rockland	7,011	1.0%
19	Belfast	6,968	1.0%
20	Gardiner	6,033	1.1%
21	Calais	3,032	0.3%
22	Hallowell	2,573	0.2%
23	Eastport	1,280	0.2%