| Rank | City | 2005 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Portland | 64,100 | -0.0% |
| 2 | Lewiston | 35,650 | 0.0% |
| 3 | Bangor | 31,119 | -0.3% |
| 4 | South Portland | 23,531 | 0.2% |
| 5 | Auburn | 23,274 | 0.1% |
| 6 | Biddeford | 22,024 | 1.1% |
| 7 | Augusta | 18,576 | 0.0% |
| 8 | Saco | 17,975 | 1.5% |
| 9 | Westbrook | 16,008 | -0.2% |
| 10 | Waterville | 15,426 | -0.3% |
| 11 | Bath | 9,309 | 0.2% |
| 12 | Presque Isle | 9,294 | -0.5% |
| 13 | Brewer | 9,110 | 0.4% |
| 14 | Caribou | 8,212 | -0.3% |
| 15 | Old Town | 7,830 | -0.2% |
| 16 | Rockland | 7,648 | 0.1% |
| 17 | Ellsworth | 6,861 | 1.5% |
| 18 | Belfast | 6,754 | 1.2% |
| 19 | Gardiner | 6,204 | 0.0% |
| 20 | Calais | 3,302 | -1.0% |
| 21 | Hallowell | 2,520 | 0.5% |
| 22 | Eastport | 1,583 | -0.8% |
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