Biggest Cities in Massachusetts

Rank	City	1880 Population	Growth Rate (Annual)
1	Boston	362,839	3.8%
2	Lowell	59,475	3.8%
3	Worcester	58,291	3.6%
4	Cambridge	52,669	2.9%
5	Fall River	48,961	6.2%
6	Lawrence	39,151	3.1%
7	Lynn	38,274	3.1%
8	Springfield	33,340	2.2%
9	Salem	27,563	1.3%
10	New Bedford	26,845	2.3%
11	Somerville	24,933	–
12	Holyoke	21,915	–
13	Chelsea	21,782	1.6%
14	Taunton	21,213	1.3%

In 1880, the largest city in Massachusetts was Boston, with a population of 362,839. The second largest city is Lowell, with a population of 59,475.