| Rank | City | 1880 Population | Growth Rate (Annual) | 
|---|---|---|---|
| 1 | Boston | 362,839 | 3.8% | 
| 2 | Lowell | 59,475 | 3.8% | 
| 3 | Worcester | 58,291 | 3.6% | 
| 4 | Cambridge | 52,669 | 2.9% | 
| 5 | Fall River | 48,961 | 6.2% | 
| 6 | Lawrence | 39,151 | 3.1% | 
| 7 | Lynn | 38,274 | 3.1% | 
| 8 | Springfield | 33,340 | 2.2% | 
| 9 | Salem | 27,563 | 1.3% | 
| 10 | New Bedford | 26,845 | 2.3% | 
| 11 | Somerville | 24,933 | – | 
| 12 | Holyoke | 21,915 | – | 
| 13 | Chelsea | 21,782 | 1.6% | 
| 14 | Taunton | 21,213 | 1.3% | 
In 1880, the largest city in Massachusetts was Boston, with a population of 362,839. The second largest city is Lowell, with a population of 59,475.
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