Rank	City	2022 Population (Est.)	Growth Rate (Annual)
1	Wilmington	70,750	-0.2%
2	Dover	38,992	-1.4%
3	Newark	31,155	-0.5%
4	Middletown	24,164	3.6%
5	Smyrna	13,149	1.6%
6	Milford	12,272	8.6%
7	Seaford	8,250	3.3%
8	Georgetown	7,413	3.4%
9	Millsboro	7,139	3.5%
10	Elsmere	6,157	-0.7%
11	New Castle	5,499	-0.6%
12	Camden	4,248	14.2%
13	Laurel	4,038	3.5%
14	Clayton	3,991	0.3%
15	Harrington	3,777	0.2%
16	Milton	3,428	3.5%
17	Lewes	3,420	3.3%
18	Selbyville	2,999	3.5%
19	Townsend	2,788	1.9%
20	Ocean View	2,752	3.6%
21	Bridgeville	2,667	3.5%
22	Delmar	2,105	3.5%
23	Cheswold	1,959	1.6%
24	Millville	1,907	3.6%
25	Delaware City	1,879	0.1%
26	Wyoming	1,801	5.8%
27	Felton	1,323	0.6%
28	Blades	1,229	3.4%
29	Bellefonte	1,220	-0.1%
30	Rehoboth Beach	1,151	3.4%
31	Frederica	1,081	0.5%
32	Greenwood	1,026	3.5%
33	Bethany Beach	997	3.5%
34	Dagsboro	908	3.4%
35	Newport	893	-0.9%
36	Frankford	828	3.8%
37	Ellendale	511	3.7%
38	South Bethany	473	3.5%
39	Arden	428	–
40	Houston	389	0.3%
41	Dewey Beach	372	3.3%
42	Odessa	361	-0.8%
43	Fenwick Island	355	3.2%
44	Bowers	278	0.7%
45	Magnolia	278	1.1%
46	Ardentown	253	-0.4%
47	Bethel	247	2.9%
48	Ardencroft	227	0.4%
49	Slaughter Beach	227	3.7%
50	Kenton	214	0.9%
51	Little Creek	194	0.5%
52	Woodside	190	0.5%
53	Leipsic	180	0.6%
54	Henlopen Acres	144	3.6%
55	Viola	139	-0.7%
56	Farmington	91	–
57	Hartly	72	1.4%