| Rank |
School District |
Population (2012) |
| 1 |
Greenville County School District, South Carolina
|
469,054
|
| 2 |
Charleston County School District, South Carolina
|
351,945
|
| 3 |
Horry County School District, South Carolina
|
270,875
|
| 4 |
Berkeley County School District, South Carolina
|
179,127
|
| 5 |
Aiken County School District, South Carolina
|
162,347
|
| 6 |
Beaufort County School District, South Carolina
|
160,762
|
| 7 |
Richland School District 2, South Carolina
|
126,568
|
| 8 |
Dorchester School District 2, South Carolina
|
121,398
|
| 9 |
Pickens County School District, South Carolina
|
119,313
|
| 10 |
Florence School District 1, South Carolina
|
99,802
|
| 11 |
Lexington School District 5, South Carolina
|
91,722
|
| 12 |
Lancaster County School District, South Carolina
|
76,755
|
| 13 |
Oconee County School District, South Carolina
|
74,217
|
| 14 |
Darlington County School District, South Carolina
|
68,547
|
| 15 |
Kershaw County School District, South Carolina
|
61,758
|
| 16 |
Georgetown County School District, South Carolina
|
60,167
|
| 17 |
Greenwood School District 50, South Carolina
|
58,195
|
| 18 |
Spartanburg School District 6, South Carolina
|
55,182
|
| 19 |
Cherokee County School District, South Carolina
|
53,068
|
| 20 |
Sumter School District 17, South Carolina
|
51,776
|
| 21 |
Anderson School District 1, South Carolina
|
46,691
|
| 22 |
Chesterfield County School District, South Carolina
|
46,621
|
| 23 |
Colleton County School District, South Carolina
|
38,796
|
| 24 |
Newberry County School District, South Carolina
|
37,574
|
| 25 |
Williamsburg County School District, South Carolina
|
34,354
|
| 26 |
Chester County School District, South Carolina
|
33,082
|
| 27 |
York School District 1, South Carolina
|
30,749
|
| 28 |
Union County School District, South Carolina
|
28,892
|
| 29 |
Marlboro County School District, South Carolina
|
28,862
|
| 30 |
Edgefield County School District, South Carolina
|
26,881
|
| 31 |
Jasper County School District, South Carolina
|
24,795
|
| 32 |
Abbeville County School District, South Carolina
|
24,749
|
| 33 |
Fairfield County School District, South Carolina
|
23,844
|
| 34 |
Orangeburg School District 3, South Carolina
|
21,729
|
| 35 |
Laurens School District 56, South Carolina
|
19,633
|
| 36 |
Lee County School District, South Carolina
|
19,176
|
| 37 |
Clarendon School District 2, South Carolina
|
18,890
|
| 38 |
Calhoun County School District, South Carolina
|
15,198
|
| 39 |
Remainder of South Carolina, South Carolina
|
15,119
|
| 40 |
Saluda County School District, South Carolina
|
14,491
|
| 41 |
Marion School District 2, South Carolina
|
11,540
|
| 42 |
Barnwell School District 45, South Carolina
|
11,510
|
| 43 |
Allendale County School District, South Carolina
|
10,548
|
| 44 |
McCormick County School District, South Carolina
|
10,178
|
| 45 |
Hampton School District 2, South Carolina
|
8,061
|
| 46 |
Bamberg School District 2, South Carolina
|
7,693
|
| 47 |
Dillon School District 1, South Carolina
|
5,164
|